Interactive 3D Visualization of Actual Anatomy and Simulated Chemical Time-Course Data for Fish

Outputs from a physiologically-based toxicokinetic (PBTK) model for fish were visualized by mapping time-series data for specific tissues onto a three-dimensional representation of a rainbow trout. The trout representation was generated in stepwise fashion: 1) cross-sectional images were obtained from an anesthetized fish using a magnetic resonance imaging (MRI) system, 2) images were processed to classify tissue types 3) images were stacked and processed to create a three-dimensional representation of the fish, encapsulating five volumes corresponding to the liver, kidney, muscle, gastrointestinal tract, and fat. Kinetic data for the disposition of pentachloroethane in trout were generated using a PB-TK model. Model outputs were mapped onto corresponding tissue volumes, representing chemical concentration as color intensity. The visualization was then animated, to show the accumulation of pentachloroethane in each tissue during a continuous branchial (gill) exposure.